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This page (revision-8) was last changed on 26-Dec-2012 11:06 by 1614216108

This page was created on 10-Apr-2012 12:31 by UnknownAuthor

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At line 3 changed 2 lines
  中文名称:血管活性肠肽\\
  英文名称:vasoactive intestinal polypeptide,VIP\\
  中文名称:血管活性肠肽  又名:[舒血管肠肽]\\
  英文名称:[vasoactive intestinal polypeptide,VIP]\\
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  1970年,Said 和Mutt在从猪小肠黏膜提取胰泌素(secretin)过程中,发现一种具有血管扩张作用的物质,经提纯鉴定为有28个氨基酸残基,分子量3381的肽类激素;与合成VIP有同样的生物学活性。VIP的化学结构与胰泌素类似,与胰高糖素、胃泌素抑多肽同属于胰泌素家族。VIP细胞广泛分布于消化管和神经组织,密布于消化管黏膜-黏膜下层和固有肌层,胆囊、胰腺、胃与食管连接部及幽门环的神经组织,输尿管、尿道口括约肌的神经组织,中枢神经的大脑皮质、视丘下部、海马回等部位。\\
  1970年,Said和Mutt在从猪小肠黏膜提取胰泌素(secretin)过程中,发现一种具有血管扩张作用的物质,经提纯鉴定为有28个氨基酸残基,分子量3381的肽类激素;与合成VIP有同样的生物学活性。VIP的化学结构与胰泌素类似,与胰高糖素、胃泌素抑多肽同属于胰泌素家族。VIP细胞广泛分布于消化管和神经组织,密布于消化管黏膜-黏膜下层和固有肌层,胆囊、胰腺、胃与食管连接部及幽门环的神经组织,输尿管、尿道口括约肌的神经组织,中枢神经的大脑皮质、视丘下部、海马回等部位。\\
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__有何用途 :__\\
  临床主要用于VIP瘤诊断和治疗监测。
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临床主要用于VIP瘤诊断和治疗监测。\\
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小于100pg/ml;\\
提取法小于50pg/ml。\\
<100pg/ml\\
提取法:<50pg/ml\\
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RIA、EIA或其他免疫标记法。Chang等用XAD-2树脂柱提取后测定可提高敏感性。\\
  RIA、EIA或其他免疫标记法。Chang等用XAD-2树脂柱提取后测定可提高敏感性。\\
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空腹(禁食水)10-12小时以上。\\
  空腹(禁食水)10-12小时以上。\\
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  EDTA盐抗凝,预冷注射器或真空采血针静脉采血。为抑制蛋白酶活性需加抑肽酶500U/1ml血,置冻壶中转送,4摄氏度,3000r/min分离血浆。如不能立即测定应零下20摄氏度冷冻可稳定2-3年;不能反复融冻。\\
  EDTA盐抗凝,预冷注射器或真空采血针静脉采血。为抑制蛋白酶活性需加抑肽酶500U/1ml血,置冻壶中转送,4摄氏度,3000r/min分离血浆。如不能立即测定应零下20摄氏度冷冻可稳定2-3年,不能反复融冻。\\
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[血.胃肠胰激素]
Version Date Modified Size Author Changes ... Change note
8 26-Dec-2012 11:06 1.309 kB 1614216108 to previous 胃肠胰激素 ==> 血.胃肠胰激素
7 25-Dec-2012 13:41 1.307 kB 1614216108 to previous | to last
6 04-May-2012 09:33 1.286 kB 1614216108 to previous | to last
5 04-May-2012 09:33 1.298 kB 1614216108 to previous | to last
4 25-Apr-2012 13:50 1.297 kB 1614216108 to previous | to last
3 25-Apr-2012 11:01 1.275 kB 1614216108 to previous | to last
2 12-Apr-2012 14:49 1.252 kB 1614216108 to previous | to last
1 10-Apr-2012 12:31 1.243 kB UnknownAuthor to last
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