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This page (revision-10) was last changed on 15-Oct-2013 14:06 by 1614216108

This page was created on 13-Apr-2012 17:27 by UnknownAuthor

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凝血酶原被凝血酶原酶转化为凝血酶时，凝血酶原分子的氨基端（N端）273位精氨酸与274位苏氨酸之间的肽键被裂解，从N端释放出片段1+2（F1+2），即一位丙氨酸至273位精氨酸的肽片段。\\
将待测血浆加入用兔抗人凝血酶原片段1+2抗体包被的酶标反应板中，再加入酶标鼠抗人凝血酶原抗体并经底物显色，其颜色的深浅与血浆F1+2的含量呈正相关。\\
　　凝血酶原被凝血酶原酶转化为凝血酶时，凝血酶原分子的氨基端（N端）273位精氨酸与274位苏氨酸之间的肽键被裂解，从N端释放出片段1+2（F1+2），即一位丙氨酸至273位精氨酸的肽片段。\\
　　将待测血浆加入用兔抗人凝血酶原片段1+2抗体包被的酶标反应板中，再加入酶标鼠抗人凝血酶原抗体并经底物显色，其颜色的深浅与血浆F1+2的含量呈正相关。\\
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　　1.血栓前状态与血栓性疾病 ①DIC:大约90%的DIC病例可见血浆F1+2含量显著增高。②急性心肌梗死(AMI)：血浆F1+2含量仅一般轻度升高。溶栓治疗后，由于溶栓介导的凝血酶形成增加，F1+2可进一步升高。若溶栓治疗有效，缺血的心肌成功实现再灌注，F1+2可锐减。③易栓症与静脉血栓形成：易栓症的F1+2可轻度升高。当并发血栓形成尤其是肺栓塞和深静脉血栓形成，血浆F1+2可明显增高。④口服避孕药和雌激素替代治疗可见F1+2升高。\\
1.血栓前状态与血栓性疾病 \\
　　①DIC:大约90%的DIC病例可见血浆F1+2含量显著增高。\\
　　②急性心肌梗死(AMI)：血浆F1+2含量仅一般轻度升高。溶栓治疗后，由于溶栓介导的凝血酶形成增加，F1+2可进一步升高。若溶栓治疗有效，缺血的心肌成功实现再灌注，F1+2可锐减。\\
　　③易栓症与静脉血栓形成：易栓症的F1+2可轻度升高。当并发血栓形成尤其是肺栓塞和深静脉血栓形成，血浆F1+2可明显增高。\\
　　④口服避孕药和雌激素替代治疗可见F1+2升高。\\
2.抗凝治疗监测 \\
　　①肝素治疗：血栓性疾病用肝素治疗时，一旦达到有效治疗浓度，血浆F1+2可由高浓度降到参考范围内。\\
　　②香豆素类抗凝药治疗：口服华法林，血浆F1+2可降到参考范围内。
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　　无特殊要求。
Version Date Modified Size Author Changes ... Change note
10 15-Oct-2013 14:06 0.983 kB 1614216108 to previous
9 15-Oct-2013 14:04 0.977 kB 1614216108 to previous | to last 血浆凝血酶原片段F1+2检测 ==> 血浆凝血酶原片段1+2检测(F1+2)
8 21-Dec-2012 13:47 0.977 kB 1614216108 to previous | to last
7 03-Dec-2012 10:59 1.02 kB 1614216108 to previous | to last 血浆凝血酶原片段F1+2 ==> 血浆凝血酶原片段F1+2检测
6 03-Dec-2012 10:59 1.02 kB 1614216108 to previous | to last
5 12-Jul-2012 10:03 0.896 kB 1614216108 to previous | to last
4 03-May-2012 13:23 0.927 kB 1614216108 to previous | to last
3 25-Apr-2012 15:29 0.919 kB 1614216108 to previous | to last
2 23-Apr-2012 15:03 0.886 kB 1614216108 to previous | to last
1 13-Apr-2012 17:27 0.744 kB UnknownAuthor to last
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