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This page (revision-16) was last changed on 21-Dec-2012 13:14 by 1614216108

This page was created on 16-Apr-2012 09:27 by UnknownAuthor

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%%tab-血浆凝血因子VIII、Ⅸ、XI、XII
　　中文名称：血浆凝血因子Ⅷ、Ⅸ、Ⅺ、Ⅻ\\
　　英文名称：plasma coagulation factorⅧ、Ⅸ、Ⅺ、Ⅻ, (FⅧ、FⅨ、FⅪ、FⅫ)。\\
%%tab-血浆凝血因子VIII
　　中文名称：血浆凝血因子VIII\\
　　英文名称：[plasma coagulation factor VIII activity]\\
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1. 血友病\\
　　FⅧ:C、FⅨ:C测定是诊断血友病A和B的重要指标。\\
2. 血管性血友病\\
　　1型和3型患者FⅧ:C显著减少，但不如血友病A明显、一般在20%～40%；2型患者FⅧ:C可正常。\\
3. FⅪ、FⅫ先天性缺陷\\
　　比较少见，FⅫ缺乏症患者易发生血栓栓塞性疾病。\\
4. 肝脏疾病 \\
　　FⅧ:C升高。\\
5. 血液高凝状态与血栓性疾病 \\
　　血浆FⅧ、FⅨ、FⅪ、FⅫ可升高。\\
6. 浓缩因子制剂治疗监测 \\
　　血友病常常需要浓缩FⅧ因子治疗，治疗过程中可进行所输入因子的凝血活性检测。发生严重出血的血友病A患者输入浓缩FⅧ因子制剂后，FⅧ:C＞5%时，一般不会自发性出血。\\
1.降低见于：\\
(1)先天性减少：血友病A、第Ⅷ因子缺乏或分子异常、性连锁显性遗传，血友病A基因携带者，通常无出血倾向，ⅧC约为50%，ⅧC与vWFAg比值较正常女性为低，血管性血友病。(2)后天性减少：抗Ⅷ因子、vWS综合征、弥漫性血管内凝血失代偿期、纤溶亢进等消耗亢进状态，严重肝病肝功能损害生成减少。\\
2.升高见于：甲亢、糖尿病、组织损伤、炎症反应、与纤维蛋白原同是急性期反应蛋白。
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FⅨ:C 98.1%±30.4%， FⅨ:Ag 98.2%±29.5%。 \\
FⅪ:C 100%±18.4%, FⅪ:Ag 97.2%±25.1%。\\
FⅫ:C 92.4%±20.7%，FⅫ:Ag 100%±22%。\\
　　凝血纠正法：FⅧC50%~150%\\
　　酶联免疫法：FⅧAg83.2±25.2U/ml或约100μg/l\\
无日内、日间、季节、性别差异，绝经期后有升高趋势，妊娠期、产褥期约增高倍。（数据来源于现代实验诊断学－检验与临床第二版，刘人伟、翁心植编）
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%%tab-医学决定水平
无。
/%
%%tab-危急值范围
无。
/%
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无特殊要求。
采血前空腹。
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标本采集：用PT试管，含3.2%(109mmol/L)枸橼酸钠0.2ml，静脉血1.8ml，或用蓝帽真空管静脉采血,不得有凝块。为避免被组织凝血活酶污染，可用双管技术采血（以第二管为准。）立即置冰块上送检。分离乏血小板血浆，2~8 ℃稳定2小时，-37 ℃稳定2周。\\
标本运送：采集后立即送到实验室。
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[凝血活性]
Version Date Modified Size Author Changes ... Change note
16 21-Dec-2012 13:14 0.92 kB 1614216108 to previous
15 03-Dec-2012 10:57 0.931 kB 1614216108 to previous | to last 血浆凝血因子VIII ==> 血浆凝血因子VIII活性测定
14 03-Dec-2012 10:57 0.931 kB 1614216108 to previous | to last
13 11-Jul-2012 16:30 0.994 kB 1614216108 to previous | to last 血浆凝血因子VIII,IX,XI,XII ==> 血浆凝血因子VIII
12 11-Jul-2012 16:14 0.994 kB 1614216108 to previous | to last
11 03-May-2012 13:22 1.025 kB 1614216108 to previous | to last
10 25-Apr-2012 15:22 1.017 kB 1614216108 to previous | to last
9 24-Apr-2012 10:53 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIII,XI,XII ==> 血浆凝血因子VIII,IX,XI,XII
8 24-Apr-2012 10:53 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIII,,XI,XII ==> 血浆凝血因子VIII,XI,XII
7 23-Apr-2012 15:00 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIIIXIXII ==> 血浆凝血因子VIII,,XI,XII
6 23-Apr-2012 15:00 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIIIIXXIXII ==> 血浆凝血因子VIIIXIXII
5 20-Apr-2012 16:43 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIIIXIXII ==> 血浆凝血因子VIIIIXXIXII
4 20-Apr-2012 16:42 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIIIIXXIXII ==> 血浆凝血因子VIIIXIXII
3 20-Apr-2012 16:40 0.984 kB 1614216108 to previous | to last 血浆凝血因子VIII、Ⅸ、XI、XII ==> 血浆凝血因子VIIIIXXIXII
2 20-Apr-2012 16:38 0.984 kB 1614216108 to previous | to last
1 16-Apr-2012 09:27 0.95 kB UnknownAuthor to last
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