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This page (revision-9) was last changed on 15-Oct-2013 13:55 by 1614216108

This page was created on 17-Apr-2012 12:54 by UnknownAuthor

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　　检测APC-R对血栓性疾病的诊断有意义。引起APC-R的原因可能是：①存在APC抗体；②存在APC的某种抑制物；③蛋白S缺乏；④由于基因突变等导致FⅤa和FⅧa不被APC灭活等。
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APC-SR＞2.0， n-APC-SR＞0.84。
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由于APC-R试验是在加入外源性APC条件下进行APTT测定，除FV Leiden突变外，蛋白S缺陷、狼疮抗凝物存在、FⅡ、FⅧ、FⅩ缺乏、口服抗凝药物治疗等均可影响试验结果，急性血栓形成或妊娠妇女由于体内止凝血系统的异常变化也可影响试验结果。为克服上述试验不足，有一种改进方法检测APC-R，方法是将待测血浆用乏FⅤ的血浆稀释后，再加入组织因子、Ca2+和活化蛋白C（APC），测定其加或不加APC的凝血酶原时间(PT)并求出其比值，可更灵敏地判断APC-R，此法对FV Leiden突变检测的灵敏度和特异性均可达到100%。\\
　　由于APC-R试验是在加入外源性APC条件下进行APTT测定，除FV Leiden突变外，蛋白S缺陷、狼疮抗凝物存在、FⅡ、FⅧ、FⅩ缺乏、口服抗凝药物治疗等均可影响试验结果，急性血栓形成或妊娠妇女由于体内止凝血系统的异常变化也可影响试验结果。为克服上述试验不足，有一种改进方法检测APC-R，方法是将待测血浆用乏FⅤ的血浆稀释后，再加入组织因子、Ca2+和活化蛋白C（APC），测定其加或不加APC的凝血酶原时间(PT)并求出其比值，可更灵敏地判断APC-R，此法对FV Leiden突变检测的灵敏度和特异性均可达到100%。\\
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无特殊要求。
Version Date Modified Size Author Changes ... Change note
9 15-Oct-2013 13:55 1.068 kB 1614216108 to previous
8 15-Oct-2013 13:54 1.056 kB 1614216108 to previous | to last 活化蛋白C抵抗试验 ==> 活化蛋白C抵抗试验(APCR)
7 21-Dec-2012 12:38 1.056 kB 1614216108 to previous | to last
6 11-Jul-2012 12:22 1.08 kB 1614216108 to previous | to last
5 11-Jul-2012 12:22 1.07 kB 1614216108 to previous | to last
4 03-May-2012 13:15 1.093 kB 1614216108 to previous | to last
3 25-Apr-2012 15:24 1.085 kB 1614216108 to previous | to last
2 19-Apr-2012 16:35 1.06 kB 1614216108 to previous | to last
1 17-Apr-2012 12:54 0.926 kB UnknownAuthor to last
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