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This page (revision-8) was last changed on 05-Dec-2012 11:22 by 1614216108

This page was created on 17-Apr-2012 12:15 by UnknownAuthor

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中文名称:抗甲状腺球蛋白抗体,抗甲状腺微粒体抗体或抗甲状腺过氧化物酶抗体\\
英文名称:antithyroglobulin antibody,TGAb;antithyroid microsomal antibody,TMAb;antithyroid peroxidase antibody,TPOAb\\
  中文名称:抗甲状腺球蛋白抗体,抗甲状腺微粒体抗体或抗甲状腺过氧化物酶抗体\\
  英文名称:antithyroglobulin antibody,TGAb;antithyroid microsomal antibody,TMAb;antithyroid peroxidase antibody,TPOAb\\
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  (1)桥本病 TGAb和TMAb是桥本病的标志性抗体,敏感性高,但特异性较低。近年证明TPO是T淋巴细胞和B淋巴细胞抗原决定基的成份,与TG共同为桥本病自身抗体的识别抗原。抗体通过活化补体或抗体依赖性细胞毒细胞的作用造成甲状腺细胞障碍。抗体水平与桥本病活动性正相关,甲状腺功能减退进展受抗体影响,但抗体效价与甲状腺功能水平并不呈平行相关。\\
  (2)弥漫性甲状腺功能亢进症(Graves病) 也有很高的阳性率。甲状腺功能正常的Graves 病、原发性甲状腺功能减退症也有较高的甲状腺自身抗体检出率。提示与桥本病有共同的免疫紊乱基础。\\
  (3)非甲状腺自身免疫性疾病 如SLS或其它抗核抗体阳性的组缔组织病、类风湿性关节炎、I型糖尿病、重症肌无力、肾上腺皮质功能减退症、恶性贫血、免疫性肝病等。\\
(1)桥本病 TGAb和TMAb是桥本病的标志性抗体,敏感性高,但特异性较低。近年证明TPO是T淋巴细胞和B淋巴细胞抗原决定基的成份,与TG共同为桥本病自身抗体的识别抗原。抗体通过活化补体或抗体依赖性细胞毒细胞的作用造成甲状腺细胞障碍。抗体水平与桥本病活动性正相关,甲状腺功能减退进展受抗体影响,但抗体效价与甲状腺功能水平并不呈平行相关。\\
(2)弥漫性甲状腺功能亢进症(Graves病) 也有很高的阳性率。甲状腺功能正常的Graves 病、原发性甲状腺功能减退症也有较高的甲状腺自身抗体检出率。提示与桥本病有共同的免疫紊乱基础。\\
(3)非甲状腺自身免疫性疾病 如SLS或其它抗核抗体阳性的组缔组织病、类风湿性关节炎、I型糖尿病、重症肌无力、肾上腺皮质功能减退症、恶性贫血、免疫性肝病等。\\
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  (4)正常人特别是女性有不到10%的阳性率,与潜在的自身免疫性甲状腺疾病有关;但敏感法也有假阳性的可能性。\\
(4)正常人特别是女性有不到10%的阳性率,与潜在的自身免疫性甲状腺疾病有关;但敏感法也有假阳性的可能性。\\
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标本采集与运送:\\
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%%tab-标本采集和运送要求
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??甲状腺球蛋白抗体IgM\\
Version Date Modified Size Author Changes ... Change note
8 05-Dec-2012 11:22 1.507 kB 1614216108 to previous 自身免疫病检验 ==> 血.自身免疫病检验
7 05-Dec-2012 11:22 1.505 kB 1614216108 to previous | to last
6 05-Dec-2012 10:54 1.505 kB 1614216108 to previous | to last
5 10-May-2012 09:41 1.505 kB 1614216108 to previous | to last
4 04-May-2012 14:30 1.503 kB 1614216108 to previous | to last
3 03-May-2012 17:30 1.515 kB 1614216108 to previous | to last
2 19-Apr-2012 17:12 1.49 kB 1614216108 to previous | to last
1 17-Apr-2012 12:15 1.498 kB UnknownAuthor to last
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