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This page (revision-4) was last changed on 07-Feb-2013 14:18 by 1614216108

This page was created on 08-Jan-2013 17:29 by 1614216108

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  查分两个阶段,首先需要证实皮质醇水平升高。这个阶段包括24小时尿皮质醇检测和低剂量地塞米松抑制试验。然后明确皮质醇增多的原因:是下丘脑生成的还是肾上腺或其它部位生成的。包括:大剂量地塞米松抑制试验,CRH刺激试验以及一次或多次影像学检查。\\
  [血浆皮质醇]\\
  [尿游离皮质醇测定]\\
  CRH 兴奋试验\\
  地塞米松抑制试验
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1.血浆ACTH和皮质醇(F)测定:库欣病患者晨间的血浆ACTH和皮质醇水平可以正常,但夜间增高。异位ACTH综合征患者的血浆ACTH水平大多增高,从轻度高于正常值上限(约为19 pmol/L)到升高8~9倍,个别患者正常。F水平与ACTH增高水平一致,在550~5 500 nmol/L之间。肾上腺皮质腺瘤、癌、不依赖ACTH的微结节和大结节增生患者血浆ACTH水平降低,可达检测水平以下(<1 pmol/L)。F水平晨间可以正常,夜间显著升高。
ACTH和F的上述改变说明库欣综合征患者已丧失了正常的分泌节律(分泌高峰在晨间)。一般地说,午夜血浆F水平>200nmol/L提示库欣综合征,<140 nmol/L基本上可以排除诊断。
2.无论是哪种类型的库欣综合征,24h尿液中的UFC一般都是增高的。
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%%tab-检验项目及组合列表
[血浆皮质醇]\\
[尿游离皮质醇测定]\\
[促肾上腺皮质激素]
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[内分泌疾病] 
Version Date Modified Size Author Changes ... Change note
4 07-Feb-2013 14:18 0.921 kB 1614216108 to previous 尿游离皮质醇 ==> 尿24小时游离皮质醇
3 07-Feb-2013 14:17 0.917 kB 1614216108 to previous | to last 尿游离皮质醇测定 ==> 尿游离皮质醇
2 30-Jan-2013 17:31 0.919 kB 1614216108 to previous | to last
1 08-Jan-2013 17:29 0.671 kB 1614216108 to last
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