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This page (revision-6) was last changed on 15-Oct-2013 15:27 by 1614216108

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1)β地中海贫血特征：患者在这种情况下1个基因正常而另1个基因发生突变。他们除了小红细胞症和可能出现轻度对铁剂治疗无反应性的贫血外无其他健康问题。这种突变可以遗传至后代。\\
1)轻度β地中海贫血特征：患者在这种情况下1个基因正常而另1个基因发生突变。他们除了小红细胞症和可能出现轻度对铁剂治疗无反应性的贫血外无其他健康问题。这种突变可以遗传至后代。\\
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__α地中海贫血__\\
1.HbH病：外周血象和骨髓象的改变类似重型β地贫；红细胞渗透脆性减低；变性珠蛋白小体阳性；HbA2及HbF含量正常。出生时血液中含有约0. 25Hb Bart's及少量HbH；随年龄增长，HbH逐渐取代Hb Bart's，其含量约为0.024～0.44。包涵体生成试验阳性。\\
2.重度α地中海贫血：外周血成熟红细胞形态改变如重型β地贫，有核红细胞和网织红细胞明显增高。血红蛋白中几乎全是 Hb Bart's 或同时有少量HbH，无 HbA、 HbA2和HbF。\\
__β地中海贫血__\\
1.轻度β地中海贫血：成熟红细胞有轻度形态改变，红细胞渗透脆胜正常或减低，血红蛋白电泳显示HbA2含量增高（0.035～0.060)，这是本型的特点。HbF含量正常。\\
2.中度地中海贫血：外周血象和骨髓象的改变如重型，红细胞渗透脆性减低，HbF 含量约为0.40～0.80, HbA2含量正常或增高。\\
3.重度地中海贫血（也称为库利氏贫血）：外周血象呈小细胞低色素性贫血，红细胞大小不等，中央浅染区扩大，出现异形、靶形、碎片红细胞和有核红细胞、点彩红细胞、嗜多染性红细胞、豪-周氏小体等；网织红细胞正常或增高。骨髓象呈红细胞系统增生明显活跃，以中、晚幼红细胞占多数，成熟红细胞改变与外周血相同。红细胞渗透脆性明显减低。HbF含量明显增高，大多>0.40，这是诊断重型β地贫的重要依据。
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%%tab-检验项目及组合列表
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[红细胞形态检查]\\
[异常红细胞形态检查]\\
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[红细胞渗透脆性试验]\\
[网织红细胞计数]\\
[血红蛋白电泳测定]
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[疾病]
[血液疾病]
Version Date Modified Size Author Changes ... Change note
6 15-Oct-2013 15:27 2.402 kB 1614216108 to previous 红细胞形态检查 ==> 异常红细胞形态检查
5 14-Oct-2013 16:11 2.4 kB 1614216108 to previous | to last 血红蛋白电泳 ==> 血红蛋白电泳测定
4 29-Jul-2013 11:06 2.398 kB 1614216108 to previous | to last
3 30-Jan-2013 11:11 2.396 kB 1614216108 to previous | to last
2 29-Jan-2013 10:15 1.721 kB 1614216108 to previous | to last
1 08-Jan-2013 17:55 1.719 kB 1614216108 to last
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