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This page (revision-14) was last changed on 30-Jul-2013 13:59 by 1614216108

This page was created on 16-Apr-2012 17:27 by UnknownAuthor

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  英文名称:\\
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  HBV基因组又称HBV DNA,由3200碱基对组成,为环状部分双股DNA,分为长的负链L和短的正链S两股。L链有4个开放读码区 (S,C,P,X区)。\\
  S区又分为前S1、前S2两区及S区,分别编码包膜上的前S1,前S2蛋白和HBsAg,三者合称为大分子蛋白;前S2蛋白与HBsAg合称为中分子蛋白;HBsAg又称为主蛋白或小分子蛋白。前S2区还编码多聚人血清白蛋白受体(PHSA-R )。\\
  C区又分为前C区与C基因,编码HBeAg和HBcAg。HBeAg是可溶性多肽,分子量17.5kDa; HBcAg是核心(核衣壳)多肽,分子量21 kDa。前C区含有起始密码子,当前C区发生突变时,在1896位的核苷酸鸟嘌呤被腺嘌呤所取代,结果TGG密码子被TA(终止密码子所取代。这时HBV仍有感染性,因为仍可表达HBcAg而不能表达HBeAg。\\
  P区编码一个碱性多肽,分子量约为90 kDa,称为DNA聚合酶( DNAP),具有逆转录酶活性。\\
  X区编码X抗原(HBxAg),内含154个氨基酸,具有反式激活作用。可反式激活其他病毒和细胞的转录。\\
  HBV基因组又称HBV DNA,由3200碱基对组成,为环状部分双股DNA,分为长的负链L和短的正链S两股。L链有4个开放读码区 (S,C,P,X区)。S区又分为前S1、前S2两区及S区,分别编码包膜上的前S1,前S2蛋白和HBsAg,三者合称为大分子蛋白;前S2蛋白与HBsAg合称为中分子蛋白;HBsAg又称为主蛋白或小分子蛋白。前S2区还编码多聚人血清白蛋白受体(PHSA-R )。\C区又分为前C区与C基因,编码HBeAg和HBcAg。HBeAg是可溶性多肽,分子量17.5kDa; HBcAg是核心(核衣壳)多肽,分子量21 kDa。前C区含有起始密码子,当前C区发生突变时,在1896位的核苷酸鸟嘌呤被腺嘌呤所取代,结果TGG密码子被TA(终止密码子所取代。这时HBV仍有感染性,因为仍可表达HBcAg而不能表达HBeAg。P区编码一个碱性多肽,分子量约为90 kDa,称为DNA聚合酶( DNAP),具有逆转录酶活性。X区编码X抗原(HBxAg),内含154个氨基酸,具有反式激活作用。可反式激活其他病毒和细胞的转录。\\
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%%tab-医学决定水平
  无。\\
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%%tab-危急值范围
  无。\\
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%%tab-病人准备
  无特殊要求。\\
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Version Date Modified Size Author Changes ... Change note
14 30-Jul-2013 13:59 1.808 kB 1614216108 to previous
13 05-Dec-2012 13:45 1.921 kB 1614216108 to previous | to last 乙型肝炎病毒e抗原 ==> 乙型肝炎病毒e抗原测定
12 05-Dec-2012 13:45 1.919 kB 1614216108 to previous | to last 乙型肝炎病毒e抗体 ==> 乙型肝炎病毒e抗体测定
11 05-Dec-2012 13:45 1.917 kB 1614216108 to previous | to last 乙型肝炎病毒表面抗原 ==> 乙型肝炎病毒表面抗原测定
10 05-Dec-2012 13:44 1.915 kB 1614216108 to previous | to last
9 24-Aug-2012 11:03 1.913 kB 1614216108 to previous | to last
8 24-Aug-2012 10:53 1.9 kB 1614216108 to previous | to last
7 24-Aug-2012 10:44 3.74 kB 1614216108 to previous | to last 乙型肝炎 ==> 乙型
6 23-Aug-2012 15:07 3.742 kB 1614216108 to previous | to last
5 27-Jul-2012 11:41 3.742 kB 1614216108 to previous | to last
4 04-May-2012 15:56 3.762 kB 1614216108 to previous | to last
3 23-Apr-2012 14:34 3.754 kB 1614216108 to previous | to last
2 20-Apr-2012 11:04 3.734 kB 1614216108 to previous | to last
1 16-Apr-2012 17:27 3.813 kB UnknownAuthor to last
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